World Well-Being High Purity Indole-3-Carbinol 99%, CAS 700-06-1, Anti-Cancer Indole-3-Carbinol

Product Description

  

Product Description

Product name: Indole-3-carbinol 98%
CAS: 700-06-1
Other names: 3-Indolylcarbinol; 1H-Indole-3-methanol; 3-Hydroxymethylindole;
3-Indolemethanol; Indole-3-methanol; I3C, indol 3 Karbinol
Molecular Formula: C9H9NO
Molecular Weight: 147.17
Storage: Store in a well-closed dry place with constant low temperature (2~8ºC) and no direct sunlight.


Description:
Indole 3-carbinol  (C9H9NO) is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables such as broccoli, cabbage, cauliflower, brussels sprouts, collard greens, and kale.  Indole-3-carbinol is also available in a dietary supplement.  Indole-3-carbinol is the subject of ongoing Biomedical research into its possible anticarcinogenic, antioxidant, and antiatherogenic effects.

Indole-3-carbinol and Cancer:
Investigation of mechanisms by which consumption of indole-3-carbinol might influence cancer incidence focuses on its ability to alter estrogen metabolism and other cellular effects. Controlled studies have been performed on such animals as rats, mice, and rainbow trout, introducing various controlled levels of carcinogens and levels of indole-3-carbinol into their daily diet.  Results showed dose-related decreases in tumor susceptibility due to indole-3-carbinol (inferred by decreases in aflatoxin-DNA binding).  The first direct evidence of pure anti-initiating activity by a natural anticarcinogen (indole-3-carbinol) found in the human diet was claimed by Dashwood et al. in 1989.
 
Indole-3-carbinol induces a G1 growth arrest of human reproductive cancer cells.  This is potentially relevant to the prevention and treatment of cancer, as the G1 phase of cell growth occurs early in the cell life cycle, and, for most cells, is the major period of the cell cycle during its lifespan.  The G1 phase is marked by the synthesis of various enzymes that are required in the next ("S") phase, including those needed for DNA replication.
 
Overuse of indole-3-carbinol supplements in the hope of preventing cancer may be unwise, as the hormone balance should be tested (via a simple blood test) before regular consumption.  Such caution is advised, due to its effect on estrogen levels (estrogen has a significant impact on brain function).
 
It promotes liver cancer in trout when it is combined with aflatoxin B1 and demotes metastasis.

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