World Well-Being Biotech ISO&FDA Certified 98% Camptothecin Camptotheca Extract

• Certification: ISO, FDA
• Assay Method: HPLC, UV
• Application Form: Tablet, Capsule
• Application: Health Care Products, Medicine
• State: Powder
• Extract Source: Camptotheca Acuminata Decne
• Model NO.: HWW2024011501
• Product Name: Camptotheca Extract
• Latin Name: Camptotheca Acuminata Decne
• Used Part: Stem
• Appearance: Light Yellow Powder
• Payment: T/T in Advance
• Shelf Life: 24 Months
• Delivery Time: 3-5 Working Days
• Free Sample: Available
• Transport Package: 25kg/Drum
• Specification: 98% Camptothecin
• Origin: Hunan, China
• Production Capacity: 2t/Month

Product Description

Product Details

Description:
Camptothecin was originally isolated from the stem wood of the Camptotheca acuminata tree and was shown to exhibit antileukemic/antitumor activity, and reversibly inhibit Mitochondrial Topo I (nuclear Topo I (topoisomerase I)) by binding to and stabilizing the topoisomerase-DNA covalent complex. Advancing replication forks are believed to interact with these complexes leading to double strand breaks, which is thought to be responsible for much of the cytotoxicity; other research has shown that some of the antitumor activity could be derived from the inhibition of NOS2 (iNOS or inducible nitric oxide synthase) which generates nitric oxide, an important regulator of angiogenesis and other biochemical pathways. The discovery of camptothecin spurred the development of many derivatives with superior activity and solubility, including irinotecan (sc-202186) and topotecan (sc-204919). Although most noted for its anticancer activity, camptothecin and derivatives have shown other pertinent biochemical actions, including: antiprotozoal, antimalarial, inhibition of HIV, upregulation of p53, and induction of apoptosis. This product also exhibits intense blue fluorescence when exposed to UV light, which could be useful in optical experiments.
 

Function
1. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
2. In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.
3. Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.
4. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as while others have been obtained satisfying curative effects in clinic.
 

Analysis	Specification	Results
Assay(Camptothecin )	≥98.0%	98.43%
Physical & Chemical Control
Identification	Positive	Complies
Appearance	Light Yellow Powder	Complies
Odor	Characteristic	Complies
Mesh Size	80 mesh	Complies
Loss On Drying	≤5.0%	2.27%
Methanol	≤5.0%	0.024%
Ethanol	≤5.0%	0.150%
Residue on Ignition	≤3.0%	1.05%
Heavy Metal Testing
Heavy Metals	<20ppm	Complies
As	<2ppm	Complies
LEAD(Pb)	< 0.5PPM	0.22 ppm
MERCURY(Hg)	Not dectect	Complies
CADMIUM	< 1 PPM	0.25 ppm
COPPER	< 1 PPM	0.32 ppm
ARSENIC	< 1 PPM	0.11 ppm
Microbiological
Total Plate Count	<1000/gMax	Complies
Staphylococcus Aurenus	Not Detected	Negative
Pseudomonas	Not Detected	Negative
Yeast & Mold	<100/gMax	Complies
Salmonella	Negative	Negative
E. Coli	Negative	Negative