Product Profile
Magnolia officinalis extract is a product extracted from the dried root bark, stem bark or branch bark of the Magnolia officinalis plant. The main ingredients are phenol, volatile oil, alkaloids, etc. It has the functions of drying dampness and eliminating phlegm, lowering Qi and eliminating fullness. It is used for dampness-stagnation injuries, epigastrium, vomiting and diarrhea, qi stagnation due to food accumulation, abdominal distension and constipation, phlegm and fluid retention, wheezing and cough.
Function
1. Muscle relaxation effect
The aqueous extract of Magnolia officinalis has a significant curare-like effect. Its alcohol extract can reduce grip strength and has a strong inhibitory effect on spasms induced by strychnine, picrotoxin and other drugs. It can relieve intestinal spasm caused by barium chloride and pilocarpine, and inhibit the contraction of isolated guinea pig bronchial smooth muscle caused by histamine. A water-soluble alkaloid isolated from Magnolia officinalis - Magnolia officinalis (also known as magnocarine) has a relaxing effect on striated muscles and can block the transmission of impulses at the motor end plate, so it has a nerve-muscle blocking effect. .
2. Central inhibitory effect
The ether extract of Magnolia officinalis can reduce the spontaneous activity of mice and antagonize the excitement caused by methamphetamine or apomorphine. Magnolol and isohonoki also have significant central inhibitory effects. Honokiol can completely inhibit spinal cord reflexes in mice, and ether extract at 0.25-1g/kg can exhibit a central inhibitory effect that eliminates any reflexes.
3. Effect on digestive system
The 50% ethanol extract of Magnolia officinalis showed a significant inhibitory effect on ethanol hydrochloride gastric mucosal ulcers, and one of its active ingredients was determined to be honokiol and magnolol.
4. Antibacterial effect
In vitro experiments of Magnolia officinalis decoction have antibacterial effects on Gram-positive bacteria such as Staphylococcus aureus, Pneumococcus aureus, and hemolytic Streptococcus aureus, and Gram-negative bacilli such as Shigella dysenteriae, Typhimurium, Escherichia coli, and Bacillus subtilis. The antibacterial effects of 62 kinds of traditional Chinese medicine powders on Staphylococcus albicans, Bacillus subtilis, Escherichia coli and Salmonella typhi were checked on a flat plate, with Magnolia officinalis having the strongest effect. Tests have shown that Magnolia officinalis also has a certain inhibitory effect on pathogenic skin fungi.
5. Exciting smooth muscle effect
Magnolia officinalis decoction has an stimulating effect on the isolated intestinal tube and bronchi of rabbits and the bronchial smooth muscle of guinea pigs. Magnolia officinalis decoction showed stimulant effect on isolated mouse intestine at a concentration of 1:166.
6. Anti-tumor effect
The three extracted components of Magnolia officinalis, lignans, magnolol, honokiol and the monoterpene magnolol, are 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein -Antagonist of Barr virus early antigen (EBv-EA) activation. Honokiol and its hydroxymethyl derivatives have significant inhibitory effects on second-stage skin tumors in mice.
7. Antihypertensive effect
When the dose of magnolialine is lower than the muscle relaxant, it has obvious antihypertensive effect. This effect cannot be counteracted by antihistamine drugs, indicating that it is not caused by the release of histamine. The antihypertensive duration of intravenous injection lasts about 10 ~15 minutes, intramuscular injection can last for more than 1 hour. The water-soluble tincture of Magnolia officinalis flower has antihypertensive effect and can accelerate the heart rate when administered intravenously or intramuscularly to anesthetized cats and rabbits.
8. Anti-caries effect
Magnolia officinalis extract was tested against the cariogenic pathogen Streptococcus mutans and was found to have an efficient and rapid bactericidal effect.
9. Anti-ulcer effect
The 5% ethanol extract of Magnolia officinalis has a significant inhibitory effect on mucosal ulcers. Honokiol has inhibitory effects on Shay's pyloric ligation, water immersion stress gastric ulcer, and duodenal spasm caused by histamine.
10. Anti-spasmodic effect
Magnolia officinalis ether extract can reduce grip strength and has a strong inhibitory effect on spasms induced by strychnine, picrotoxin, pentylenetetrazole and other drugs.
Certificates of Analysis
| Product Name: |
Magnolia Bark Extract |
Latin Name: |
Magnolia officinalis Rehd.et Wils. |
| Part used: |
Bark |
Country of origin |
China |
| |
| Item |
Specification |
Result |
| Assay |
10% Honokiol |
HPLC |
| Physical & Chemical |
| Appearance |
Brownish yellow powder |
Conforms |
| Odor & Taste |
Characteristic |
Characteristic |
| Particle Size |
90% through 80 mesh |
Conforms |
| Loss on Drying |
≤5.0% |
1.32% |
| Ash |
≤5.0% |
2.11% |
| Heavy metals |
| As |
≤2ppm |
Conforms |
| Lead (Pb) |
≤2ppm |
Conforms |
| Cadmium(Cd) |
≤1ppm |
Conforms |
| Microbiological Test |
| Total Plate Count |
NMT 1000cfu/g |
Conforms |
| Total Yeast & Mold |
NMT 100cfu/g |
Conforms |
| E.Coli |
Negative |
Negative |
| Salmonella |
Negative |
Negative |
| Pesticide Residue |
Negative |
Negative |
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