World Well-Being Wholesale Bulk 98% Oleanolic Acid Ligustrum Extract

• Customization: Available
• Certification: ISO, FDA, Sc(OS)/Jy/Kosher/Halal
• Assay Method: HPLC, UV
• Model NO.: HWW-2022111866
• Application Form: Tablet, Capsule
• Application: Food, Health Care Products, Medicine
• State: Powder
• Extract Source: Fruit
• Transport Package: 25kg/Drum
• Specification: 10: 1
• Trademark: World Well-being
• Origin: Hunan
• Production Capacity: 10t/Month

Product Description

   Oleanolic acid is a pentacyclic triterpenoid compound isolated from the fruit of Gentianaceae plant Swertia genus Pleurotus chinensis or the fruit of Ligustrum lucidum. in a plant.
   Oleanolic acid exists widely in plants, with a general content of 0.2% to 2% [1]. Cucurbitaceae plants have a higher content of 1.5% to 2% at the bottom of the hunchback, and 0.6% to 0.7% of the fruit of Ligustrum lucidum. Oleanolic acid is white needle crystal (alcohol), odorless and tasteless. Unstable to acid and alkali. Melting point 308~310ºC, [α]20D+73.3° (c=0.15, chloroform), insoluble in water, soluble in methanol, ethanol, ether, acetone and chloroform.

Specification

Items	Standard	Results
Odor	Characteristic	Conforms
Ash	≤5%	Conforms
Loss on drying	≤7%	Conforms
Metal detection:
Total Heavy Metals	≤10ppm	Conforms
As	≤2ppm	Conforms
Pb	≤2ppm	Conforms
Hg	≤0.1ppm	Conforms
Cd	≤2ppm	Conforms
Microbial Detection:
Total Plate Count	≤1000cfu/g	Conforms
Yeasts and Molds	≤100cfu/g	Conforms
E. coli	Negative	Conforms
Salmonella	Negative	Conforms
Staphylococcus	Negative	Conforms

Pharmacological Effects
Reduce Liver Damage
Oleanolic acid is a pentacyclic triterpenoid compound, which has obvious protective effect on acute and chronic liver damage in rats caused by carbon tetrachloride. After treatment, enlarged mitochondria and expanded rough endoplasmic reticulum were restored. It can also significantly reduce the hepatocellular ballooning degeneration, necrosis and inflammatory response of acute and chronic liver injury. The accumulation of triglycerides in the liver decreases and the amount of glycogen increases.
Reduce Serum Alanine Aminotransferase Activity
Oleanolic acid has obvious enzyme-lowering effect on animals with acute and chronic hepatitis and liver cirrhosis.
The reduction of serum r-globulin is consistent with the reduction of liver-related inflammatory reactions seen in histological observations.
Promote Regeneration of Liver Cells
Oleanolic acid can significantly increase the number of mitotic phases in the residual liver of rats, and the degree of regeneration is higher than that of the control group, suggesting that it has the effect of promoting cell regeneration.
Reduce the level of tyrosine in brain homogenate of rats with liver cirrhosis: Since the level of tyrosine in brain homogenate is significantly reduced, it can inhibit the generation of false neurotransmitters, so it is beneficial to the prevention and treatment of hepatic encephalopathy.
Inhibition of Hepatic Fibrosis
In rats with liver fibrosis treated with oleanolic acid, the liver fibrosis was severe and significantly reduced, and the content of liver collagen decreased, suggesting that it has the effect of preventing and treating liver cirrhosis.

Oleanolic acid has obvious inhibitory effects on mouse mononuclear phagocyte system, macrophage phagocytosis and experimental arthritis, but has effects on heterosexual humoral immune function and antigen-binding cells. Enhance immunity and inhibit the growth of S180 tumor strain.It has a protective effect on chromosomal damage, a preventive effect on experimental atherosclerosis, and can correct protein metabolism disorders.

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