Natural Fo Ti Extract 10% 20% 50% 90% 98% Stibene Glucosides Polygonum Multiflorum Thunb Polygonum Multiflorum Extract

• Certification: ISO, FDA
• Assay Method: HPLC, UV, Tlc
• Application Form: Tablet, Capsule
• Application: Food, Health Care Products, Medicine
• State: Brownish Yellow Powder
• Extract Source: Root
• Payment: T/T in Advance
• Shelf Life: 24 Months
• Delivery Time: 3-5 Working Days
• Free Sample: Available
• Transport Package: 25kg/Cardboard Drum I. D. 42cm X H. 52cm
• Specification: 5% 10% 20% Tanshinone IIA 5-70% Salvianolic Acid B
• Trademark: Shanghai, China
• Origin: China
• HS Code: 13021990
• Production Capacity: 20 Ton/Month

Product Description

Product Profile
Polygonum multiflorum extract is the dried root tuber of Polygonum multiflorum plant. Its main functional ingredients are lecithin, emodin, rhein and other ingredients. Main effects: anti-aging effects, effects on the immune system, hypolipidemic and anti-atherosclerotic effects, cardioprotective effects, hepatoprotective effects, neuroprotective effects, and antibacterial effects.

Pharmacological effects
1. Anti-aging effect
Aging animals accumulate a large amount of lipid peroxidation products, accompanied by a decrease in superoxide dismutase activity. Experimental results show that Polygonum multiflorum can significantly reduce the content of malondialdehyde in the brain and liver tissue of aged mice, increase the content of monoamine transmitters in the brain, enhance SOD activity, and can also significantly inhibit the activity of monoamine oxidase-B in the brain and liver tissue of aged mice. activity, thereby eliminating the damage caused by free radicals to the body and delaying aging and disease. The free radical theory believes that the generation and deposition of lipid peroxides can cause a series of aging symptoms. Therefore, the content of lipid peroxides is one of the main indicators for evaluating aging. Polygonum multiflorum extract has an effect on lipid peroxidation in mouse skin. It has a very obvious inhibitory effect on the production of substances, indicating that Polygonum multiflorum has the effect of delaying skin aging and can be used as a good skin anti-aging cosmetic additive. In addition, Polygonum multiflorum can significantly improve the DNA damage repair ability of peripheral lymphocytes in aged rats. By inhibiting the activity of monoamine oxidase-B in the brain, it affects the content of central neurotransmitters in the body, thereby regulating central nervous activity and delaying brain aging.
2. Impact on the immune system
Polygonum multiflorum can antagonize the atrophy and degeneration of mouse thymus caused by the immunosuppressants hydrocortisone or prednisolone, increase the weight of thymus, adrenal gland, spleen and abdominal lymph nodes, increase the total number of white blood cells, and promote phagocytosis of peritoneal macrophages. Function, reducing the content of circulating immune complexes in mice. Immunology believes that the decline of immune function is closely related to the aging of the body. The thymus is the central organ of the immune system and can effectively maintain the body's immune function. Polygonum multiflorum can delay the thymus degeneration that occurs with aging, which may be an important mechanism for delaying aging and improving the body's immunity. In addition, Polygonum multiflorum can also increase the content of thymus nucleic acid and protein, delay the age-related degeneration of the thymus in aged rats, and promote the significant reversal of changes in the ultrastructure of the thymus in aged mice, causing a significant increase in the phagocytosis index of peritoneal macrophages in mice, thereby improving The body's non-specific immune function.
3. Lowering blood lipids and anti-atherosclerosis effects
Experimental studies have shown that oral administration of Polygonum multiflorum alcohol extract at 0.84-8.4g/kg·d can significantly reduce plasma triglyceride and free cholesterol levels in aged quail within 6 weeks, and inhibit the increase in plasma total cholesterol and cholesterol esters. . The aqueous extract of Polygonum multiflorum can significantly increase the serum high-density lipoprotein cholesterol content and reduce the TC level in mice. Combined with the significant increase in the HDL-C/TC ratio, it is suggested that Polygonum multiflorum can improve the body's ability to operate and remove cholesterol, and reduce blood lipid levels. Delays the development of atherosclerosis.
4. Myocardial protection
Studies have found that polygonum multiflorum extract has a preventive effect on canine myocardial ischemia-reperfusion injury. The key to its action may be that the stilbene glycosides and resveratrol glycosides in Polygonum multiflorum have the function of increasing the activities of superoxide dismutase (SOD) and catalase. In addition, certain components in Polygonum multiflorum, such as anthraquinones and phospholipids, have direct antioxidant effects and reduce oxygen free radicals in the body.
5. Hepatoprotective effect
The stilbene glycosides contained in Polygonum multiflorum have a significant antagonistic effect on the fatty liver and liver function damage in rats caused by peroxidized corn oil, as well as the increase in liver peroxidized lipid content and the increase in serum alanine aminotransferase and aspartate aminotransferase. It can significantly reduce serum free fatty acids and liver peroxidized lipids. In in vitro experiments, it can also inhibit the peroxidation of rat liver microsomal lipids caused by adenosine diphosphate and reduced coenzyme, reduce liver cell damage and have a good hepatoprotective effect. In addition, Polygonum multiflorum is rich in lecithin, which can supplement or promote the synthesis of various liver diseases caused by lecithin reduction, and prevent and treat fatty liver and cholesterol deposition. Polygonum multiflorum increases the effect of liver glycogen, which is also beneficial to the protection of the liver.
6. Neuroprotective effect
The main active ingredient in Polygonum multiflorum: stilbene glycoside has a significant antagonistic effect on the decrease in nerve cell survival rate and the increase in lactate dehydrogenase leakage caused by β-amyloid and hydrogen peroxide. And as the dose increases, its neuroprotective effect increases. It is suggested that stilbene glycosides have a certain effect in the prevention and treatment of neurological degenerative diseases such as Alzheimer's disease. Polygonum multiflorum extract can inhibit the production of interleukin and nitric oxide in a concentration-dependent manner, thus exerting neuronal protection.
7. Antibacterial effect
Water decoctions of different processed products of Polygonum multiflorum are effective against Staphylococcus aureus, Staphylococcus albus, Shigella flexneri, Shigella sonnei, Bacillus typhi 901, Bacillus paratyphoid B, Bacillus diphtheriae, beta-hemolytic Streptococcus, and Catarrhalis neri. Bacteria have varying degrees of inhibitory effects. Among them, the decoction of raw Shouwu is stronger against Staphylococcus aureus than other processed products, while the decoction of prepared Shouwu is effective against Staphylococcus albus, the decoction of steamed Shouwu and rehmannia glutinosa juice are effective against Staphylococcus aureus. The decoction of steamed multiflorum multiflorum has better inhibitory ability against diphtheria bacilli than the raw product and other processed products.
8.Other functions
Polygonum multiflorum has an adrenocortical hormone-like effect. Preparation of polygonum multiflorum can significantly increase the liver glycogen content of adrenal starved mice, significantly increase the weight of the adrenal glands of mice, and resist thymus, Adrenal atrophy. In addition, the anthraquinone derivatives contained in Polygonum multiflorum can promote intestinal peristalsis and have a mild laxative effect.
Certificates of Analysis
 

Product Name:	Polygonum multiflorum extract		Latin Name:		Polygonum Multiflorum Thunb
Part used:	Fruit		Country of origin		China
Item		Specification		Result
Assay		5% Danshensu		HPLC
Physical & Chemical
Appearance		Brownish yellow powder		Conforms
Odor & Taste		Characteristic		Characteristic
Particle Size		90% through 80 mesh		Conforms
Loss on Drying		≤5.0%		1.32%
Ash		≤5.0%		2.11%
Heavy metals
As		≤2ppm		Conforms
Lead (Pb)		≤2ppm		Conforms
Cadmium(Cd)		≤1ppm		Conforms
Microbiological Test
Total Plate Count		NMT 1000cfu/g		Conforms
Total Yeast & Mold		NMT 100cfu/g		Conforms
E.Coli		Negative		Negative
Salmonella		Negative		Negative
Pesticide Residue		Negative		Negative