Anti-Tumor Polygonatum Odoratum Extract 10: 1-50: 1 Polysaccharide 2%-98% Anti-Aging

• Certification: ISO, FDA, SGS,Halal,Sc&Bl
• Assay Method: HPLC, UV, Tlc
• Application Form: Tablet, Capsule
• Application: Food, Health Care Products, Medicine
• State: Light Yellow Powder
• Extract Source: Fruit
• Payment: T/T in Advance
• Shelf Life: 24 Months
• Delivery Time: 3-5 Working Days
• Free Sample: Available
• Transport Package: 25kg/Cardboard Drum I. D. 42cm X H. 52cm
• Specification: 10: 1-50: 1 Polysaccharide 2%-98%
• Trademark: Shanghai, China
• Origin: China
• HS Code: 13021990
• Production Capacity: 20 Ton/Month

Product Description

Product Profile
Polygonatum odoratum extract is extracted from the dried rhizome of Polygonatum odoratum (Mill.) Druce, a plant in the Liliaceae family. The main active ingredient is Polygonatum odoratum polysaccharide.

Polygonatum odoratum is the dried rhizome of Polygonatum odoratum (Mill.) Druce, a plant in the Liliaceae family. Also known as tail ginseng and jade ginseng. It grows in mountains and forests or in rock crevices. It likes shady and humid places. It is distributed in most parts of my country. It was first recorded in the "Shen Nong's Materia Medica" under the name of wiltwort, and was listed as top grade. It is neutral in nature and sweet in taste, and has the functions of nourishing yin, moistening dryness, promoting body fluids and quenching thirst. It is used for lung and stomach yin injuries, dry-heat cough, dry throat and thirst, and internal heat to quench thirst. Modern pharmacological studies have proven that Polygonatum odorifera has the main functions of strengthening the heart, lowering blood pressure, lowering blood sugar, lowering blood lipids and enhancing immune function. It is very beneficial to patients with diabetes, hypertension and hyperlipidemia. It is a medicinal and food-use drug announced by the Ministry of Health87 One of the plants.

Function
1. Hypoglycemic effect
Polysaccharide polysaccharide has hypoglycemic and anti-oxidative stress effects. It has a significant protective effect on pancreatic B cell damage in diabetic rats caused by alloxan. It dose-dependently improves the weight loss of diabetic rats and reduces fasting blood sugar. and MDA content in pancreatic tissue, and enhance the activities of SOD, GSH-Px, and CAT. Polygonatum odoratum extract A can reduce blood sugar in type 1 diabetic mice by restoring the balance of CD4+ and CD8+ T lymphocyte subsets and regulating cytokine levels during the disease process. The total extract of Polygonatum odoratum and its chloroform separated parts have obvious hypoglycemic effects and have obvious protective effects on kidney disease, among which the chloroform separated parts last longer. Total saponins of Polygonatum odorifera lower the blood sugar in mice with hyperglycemia induced by alloxan by inhibiting α-glucosidase activity.

2. Antioxidant effect
Polygonatum monomer compounds ferulic acid tyramide and high isoflavones have a significant protective effect on PC12 cells caused by oxygen free radicals, and the cell survival rate is significantly increased. Polygonatum odorifera water extract can, to a certain extent, reduce the damage to keratinocytes caused by medium-wave ultraviolet rays and inhibit the decrease in fibroblast activity caused by long-wave ultraviolet rays. The mechanism may be to inhibit oxidative damage, enhance cellular antioxidant capacity, and reduce inflammatory cytokines. secretion. The crude extract of Polygonatum odoratum glycoprotein has certain antioxidant activity, which can increase the activities of SOD, CAT and GSH-Px in the serum, liver and brain of mice, and reduce the MDA content.

3. Immunomodulatory effect
Polygonatum odorifera extract can enhance immune function, improve thymus, spleen quality, macrophage phagocytosis percentage and phagocytosis index in mice with cyclophosphamide-induced immunosuppression, promote the formation of hemolysin and hemolytic plaques, and increase lymphocyte transformation rate. Polygonatum odoratum extract can significantly inhibit the transformation and proliferation of T lymphocytes and reduce the release of liver damage cytokines in a dose-dependent manner, thus exerting a liver protective effect.

4. Anti-tumor effect
Polygonatum odorifera extract has significant anti-tumor effects and can inhibit the proliferation of human esophageal cancer cell Eca-109 and induce its apoptosis. It can promote the secretion of IL-2 by tumor-bearing mouse cells and the secretion of IL-1 by peritoneal macrophages. , TNF-α to enhance cellular immune function, directly induce tumor cell apoptosis and promote apoptosis of human colon cancer CL-187 cells.

5. Anti-aging effect
Polysaccharide polysaccharide can increase the activity of serum superoxide dismutase in aging mice, enhance the scavenging ability of free radicals, inhibit lipid peroxidation, and reduce MDA content. At the same time, it has a certain regulatory effect on the immune function of subacute aging mice. , can improve immune imbalance, enhance cellular and humoral immune function, thereby delaying aging. Polygonatum odorifera water extract can reduce oxidative damage in D-galactose-induced subacute aging mouse model, protect liver cell mitochondrial DNA, and delay body aging.

6. Effect on cardiovascular system
Polygonatum odoratum decoction has a positive inotropic effect on isolated frog hearts and isolated rat hearts. Polygonatum odorifera total glycosides can significantly improve the diastolic and systolic function of rat myocardium. Rat serum containing 4% Polygonatum odoratum can slow down the heart rate of neonatal rat cardiomyocytes, indicating that Polygonatum odoratum has a certain effect on improving myocardial function; rat serum containing 1%, 2% and 4% Polygonatum odorifera can significantly reduce lactic acid Dehydrogenase content can reduce the damage caused by hypoxia and sugar deficiency to myocardial cells.

7.Other functions
80% ethanol extract of Polygonatum odoratum has the effect of activating tyrosinase. Its activation rate of tyrosinase at the level of 5mg (equivalent to the original dosage of 10mg·mL-1) reaches 29%; whether Polygonatum odoratum can increase tyrosinase The kinetic observation results of acidase activity indicate that Polygonatum odoratum can promote the binding of tyrosinase and substrate to accelerate the reaction rate. Therefore, Polygonatum odoratum can be used in the clinical treatment of pigment deficiency diseases and catecholamine neurotransmitter synthesis disorders caused by reduced or decreased tyrosinase activity; its activation effect on tyrosinase suggests that Polygonatum odoratum may be Is a potential drug for the treatment of vitiligo. Polygonatum odoratum extract (EC-PAOA, polysaccharide alcohol aqueous extract, a polysaccharide component) can significantly inhibit the proliferation of eutopic endometrial cells in patients with endometriosis. In vitro experimental studies have shown that EC-PAOA can reduce the expression of multifunctional cytokine L-6 and endometrial epithelial cell-specific protein CA-125, which are most closely related to endometriosis, thereby promoting the formation of new blood vessels in the lesion. Reduce and accelerate the necrosis of ectopic lesions, promote the absorption of local inflammation, and reduce pelvic adhesions; at the same time, it reduces the local estrogen content of ectopic lesions, hinders the growth of ectopic cells, effectively controls the development of endometriosis, and further improves the abdominal cavity. The internal environment causes the cellular components in the peritoneal fluid to transform to normal.

Certificates of Analysis
 

Product Name:	Polygonatum Odoratum Extract		Latin name		Polygonatumodoratum (Mill.) Druce
Part used:	Fruit		Country of origin		China
Item		Specification		Result
Assay		10:1		TLC
Physical & Chemical
Appearance		Light Yellow Powder		Conforms
Odor & Taste		Characteristic		Characteristic
Particle Size		90% through 80 mesh		Conforms
Loss on Drying		≤5.0%		1.32%
Ash		≤5.0%		2.11%
Heavy metals
As		≤2ppm		Conforms
Lead (Pb)		≤2ppm		Conforms
Cadmium(Cd)		≤1ppm		Conforms
Microbiological Test
Total Plate Count		NMT 1000cfu/g		Conforms
Total Yeast & Mold		NMT 100cfu/g		Conforms
E.Coli		Negative		Negative
Salmonella		Negative		Negative
Pesticide Residue		Negative		Negative