| Certification: | ISO, FDA |
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| Assay Method: | HPLC, UV |
| Application Form: | Tablet, Capsule |
| Application: | Health Care Products, Medicine |
| State: | Powder |
| Product Name: | Valerian Extract |
| Samples: |
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| Customization: |
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Audited Supplier | Description: It is a perennial and herbaceous plant which measures 50 to 100 cm in height. It is sparingly branched. The plant has light green central stem which is terete, stout, finely ribbed, pubescent and glabrous. An interior stem is hollow. Leaves are odd to pinnate having 4 to 9 pairs of sessile leaflets. Leaves measures about 8 inches long. Leaflets are linear to lanceolate to lanceolate to oblong in shape with smooth and sparingly dentate margins. An upper surface of leaflet is glabrous, medium and dark green whereas the lower surface is glabrous, slightly hairy and is pale. Lower and basal leaves possess longer petioles in comparison to upper leaves. Sometimes latter are sessile. The panicles of pedicles and peduncles are glabrous, pubescent and light green. Flowers are trumpet shaped, light pink or white measuring 4 mm long. Corolla has five spreading lobes and short green calyx have 3 stamens, 5 teeth and pistil with a style. Flowers are fragrant and blooms during summer for a month or two. Flowers are then replaced by achenes of 4 mm long, lanceoloid shape and slightly flattened with feathery hairs. It has rhizomatous and fibrous root system. Sometimes rhizomes produce colonies of clonal plants. Flower and Fruit Flowers are pink to white, androgynous which are in panicled cymes. Calyx is made up of 10 revolute tips. Corolla is in funnel shaped having five sectioned margin. Tube has a bump at a base. An ovary has three chambers and is inferior. There are three stamens. Fruit is indehiscent, ovate to oblong in shape, yellow and have 10 rayed tuft of white hair. Leaves, stem and root Plant grows about 500 to 100 cm high with a short and cylindrical rhizome having finger length and bushy round roots. Stem is unbranched and erect. Leaves are odd to pinnate having 11 to 23 lanceolate and indented-dentate leaflets. Upper ones are sessile and clasping with white sheath and lower ones are petiolate. Health Benefits: Acts as anticonvulsant The extracts of Valerian featured anticonvulsant properties. The study was conducted to examine anticonvulsant properties of valerian extracts and valerenic acid and for determining whether the preparations of Valerian interact with anti-epileptic drugs activity. An adult zebrafish as an animal model was studied to find out the potential of antiepileptic drugs. In adult zebrafish, valerian and valerenic acid promote latency to PTZ induced seizure in a concentration dependent manner having more potent ethanolic extract. The extracts of ethanolic valenian potentiate antiepileptic effects of both clonazepa-m and phenytoin. Valerenic acid and valerian preparations interacted co-operatively having minimal concentration of clonazepa-m to promote latency to convulsions and upgrade survival. The results shows new therapeutic alternatives for epileptic patients. Treatment for Parkinson's disease Parkinson's disease is a neurodegenerative disorders which has become a common problem. The experiments reported cytoprotective effects of Valerian extracts for Parkinson's disease. Moreover, considering Parkinson's disease as a result of mitochondrial metabolic imbalance and oxidative stress, genomic approach for evaluation of possible underlying mechanisms of plant extract effect was added. The results brought new approach to Valerian extract and suggested that hesperidin and linarin have the ability to relieve oxidative stress effects during depletion of ATP because of its ability to bind SUR1. Additionally, vital role of valerenic acid and apigenin helps to prevent cortical hyperexcitation by activating neuronal cells from SN to release GABA on brain stem. Under oxidative stress, hyperexcitability and asphyxia, Valerina triggers various mechanisms for providing protection to neuronal cells. Cardiovascular health Valerian is a flowering plant which is renowned for its essential oils and iridoid compounds such as sesquiterpenes, monoterpenes, alkaloids, flavonoids, lignanoids and amino acids. Valerian displayed various biological activities such as lowering blood pressure, heart rate, antiarrhythmia, antimyocardial ischemia reperfusion injury and regulation of blood lipid levels. The review targets on chemical constituents as well as cardiovascular activities of Valerian. Valerian contains various bioactivities which have been discussed by its complex and various active ingredients. Though the effects of Valerian affected cardiovascular system, still further investigation is required for its mechanism of action. Cure for insomnia Insomnia has affected about one third of the population. It results in increasing rate of social disability, health care use and abseentism. The root extracts of Valerian are used to promote sleep and the sleep quality. The trials showed the use of Valerian to improve quality of sleep. The evidence shows that Valerian might promote quality of sleep without showing side effects. Further studies should show range of doses of standardized preparations of Valerian and involve standard measures of safety and sleep quality. Future studies of Valerian should be granted for high priority as insomnia is given high predominance worldwide. Helpful for depression Neuroimmune facts are the contributors of depression. Beside its therapeutic effects, Valerian showed anti-inflammatory properties. The study showed the effects of Valerian's hydro alcoholic extract on depression in ovalbumin sensitized rats. Results also supported traditional belief on the beneficial effect of Valerian on nervous system. Future studies are still needed to determine protective effect of Valerian. Treatment for anxiety Valerian root promotes amount of chemical known as gamma aminobutyric acid in brain. GABA assists in regulation of nerve cells and calms anxiety. Valerian root extract has valerenol and valerenic acid which acts as anti-anxiety agents. Valerian root possess anti-anxiety effects like prescription drugs without any serious side effects. Reduce blood pressure Valerian root helps to calm body as well as mind. It also lowers blood pressure by improving heart health. The active components found in Valerian root are effective for anxiety and stress management which helps to regulate blood pressure. High blood pressure increases the chances of getting stroke and heart attack. The supplements of Valerian root reduces blood pressure naturally and normalizes at healthy level that have positive impact on heart health. Lower menstrual cramps Valerian root has relaxing properties which provides relief from menstrual cramps. It lowers the severity as well as discomfort of menstrual cramps that has become common for women who suffer from PMS. Being a natural antispasmodic and sedative, it suppresses muscle spasms and relaxes muscles. Valerian root helps to calm severe uterine muscle contractions which cause terrible pain in women that experience during menstruation. Reduce stress Valerian root helps to lower anxiety and promotes length and quality of sleep with regular management of stress. Chronic stress makes feel anxiety which makes feel more stressed. With an improvement in GABA levels, it relaxes both body as well as mind. Valerian root lowers stress and improves quality of life. According to research, valerian root helps to restrain both psychological and physical stress. |
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| Analysis Items | Specifications | Results | Methods used | ||||
| Identification | Positive | Conforms | TLC | ||||
| Appearance | Fine Dark Brown Powder | Conforms | Visual test | ||||
| Odor & Taste | Characteristic | Conforms | Organoleptic test | ||||
| Particle Size | 100% through 80 Mesh | Conforms | AOAC 973.03 | ||||
| Solubility | Soluble in Ethanol & Water solution | Conforms | Visual | ||||
| Valerianic acids | NLT 0.2% | 0.209% | UV | ||||
| Loss on Drying | NMT 5.0% | 3.43% | 5g /105ºC /2hrs | ||||
| Ash Content | NMT 5.0% | 3.47% | 2g /525ºC /3hrs | ||||
| Extract Solvents | Ethanol & Water | Conforms | / | ||||
| Heavy Metals | NMT 10ppm | Conforms | Atomic Absorption | ||||
| Arsenic (As) | NMT 1ppm | Conforms | Atomic Absorption | ||||
| Lead (Pb) | NMT 1ppm | Conforms | Atomic Absorption | ||||
| Cadmium (Cd) | NMT 0.5ppm | Conforms | Atomic Absorption | ||||
| Mercury(Hg) | NMT 0.2ppm | Conforms | Atomic Absorption | ||||
| Microbiological Data | Total Plate Count<1,000cfu/g | < 310 cfu/g | GB 4789.2 | ||||
| Total Yeast & Mold<100cfu/g | < 44 cfu/g | GB 4789.15 | |||||
| E. Coli to be negative | Negative | GB 4789.3 | |||||
| Staphylococcus to be negative | Negative | GB 4789.10 | |||||
| Salmonella to be negative | Negative | GB 4789.4 | |||||
| Packing and Storage | Packed in fiber drum, LDPE bag inside. Net weight: 25kgs/drum. | ||||||
| Keep tightly sealed, store away from moisture, strong heat and sunlight. | |||||||
| Shelf Life | 2 years if sealed and stored in the recommended conditions. | ||||||
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