PQQ Profile
Pyrroloquinoline quinone disodium salt, referred to as PQQ, is known as the fourteenth vitamin. It has a variety of biological functions. It is not only a biological conditional nutrient and redox regulator, but also a new prosthetic group that can promote the growth of enzymes. , plays a transmission function in enzymatic reactions and can stimulate the growth of microorganisms, so it is often used as a growth-promoting factor.
Product Name:Pyrroloquinoline Quinone
Appearance: Reddish-brown powder
Product specification: 98%
Detection method HPLC
Efficacy and function
1. Super antioxidant ability
PQQ has a strong ability to scavenge superoxides and can effectively scavenge HO• and O2•-. Specifically, it protects mitochondria from oxidative damage; inhibits lipid peroxides; and protects cardiomyocytes from ischemia-reperfusion. damage; protect the redox site of oxidized NMDA receptors, thereby promoting the recovery of spinal cord injury, preventing cerebral ischemia and hypoxia, and avoiding severe shock in animal models; at the same time, PQQ can also protect the heart from myocardial ischemia and myocardial infarction. Infarction, these protective effects are attributed to the antioxidant capacity of PQQ.
2. Liver protection
PQQ can protect the liver against alcohol- and carbon tetrachloride-induced liver damage and TAA-induced liver fibrosis.
3. Neuroprotective effect
PQQ can improve neuronal damage caused by oxygen and glucose deprivation models, reduce changes in Nissl body content caused by D-galactose treatment, inhibit neuronal degeneration, and have a weakening effect on nerve damage caused by β-amyloid protein. Helps promote the secretion of neurotrophic factors; in addition, PQQ can also significantly improve the memory function of rats, and has obvious effects on memory retention and dementia prevention.
4. Improve reproductive performance
People gave primiparous female rats a PQQ-deprived diet. It was found that if the female rats' diet was deficient in PQQ, they would suffer from reproductive disorders. After mating and giving birth, the newborn rats would show symptoms such as delayed growth and poor development. In addition, the female rats also Infertility or cannibalism of newborn rats may occur. If an appropriate amount of PQQ is supplemented at this time, the growth of the young rats, the fertility and behavior of the female rats will be improved, and the growth of the young rats will gradually become normal. When fed sufficient amounts of PQQ, the reproductive capacity and litter size of female rats were significantly higher than those of the control group.
5. Growth factor-like effects
Dietary deprivation of PQQ in maternal rats will cause symptoms such as growth retardation and developmental dysplasia in newborn rats. Lack of PQQ in the diet will also lead to a large decrease in the content of lysine oxidase in the skin of rats, resulting in a reduction in skin collagen content and elastin cross-linking. Joint damage manifests as fragile and peeling skin, sparse hair, bent body, hunched back, severe abdominal bleeding and even death. Therefore, PQQ is an essential nutritional factor for animal growth and development. When the mother supplements sufficient amounts of PQQ, a significant increase in the body weight of the young mice can be observed. In addition, the presence of PQQ has also been found in human milk, suggesting that PQQ plays a very important role in the growth and development of young animals.
6. Anti-inflammatory function, enhance immune regulation of the body
PQQ can scavenge ROS and resist inflammatory damage caused by oxidative stress. Injecting PQQ before injecting carrageenan into mice can reduce the inflammatory response in mouse paws caused by carrageenan. When PQQ is lacking in the diet, the content of interleukin 2 in mice is significantly reduced. When PQQ is added, spleen cells respond better to mitogen A and lipopolysaccharide. Adding PQQ to parenteral nutrition can increase Peyer's patches. The number of lymphocytes, as well as CD4+ and CD8+ cells in Peyer's patches, can be restored to a certain extent, and the integrity of lymphoid organs related to the intestines can be restored.
Application
PQQ is mainly used in the fields of pharmaceutical raw materials,health care food,dietary supplements.
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