| Customization: | Available |
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| Certification: | ISO, FDA, Hahal, Food Manufacturing License, Business Licens |
| Assay Method: | HPLC, UV |
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Description 4-Aminobutyric acid is a γ-amino acid and monocarboxylic acid derived from butyric acid • It is an amino acid that shows inhibitory activities against neurotransmitters, including GABA, and acts by binding GABA-A receptor and inhibiting the activity of signal-receiving neurons • This compound, converted from neurotransmitter glutamate, is essential to regulate neuronal excitability • It binds to GABA-A and GABA-B receptors, causing ion channel opening, hyperpolarization, and eventually inhibition of neurotransmission Applications • 4-Aminobutyric acid has been used in the preparation of GABA-BSA (bovine serum albumin)-GA (glutaraldehyde) conjugate, which is used as a control for immunohistochemical experiments • It is used, in vivo, to detect GABA neurotransmitter by magnetic resonance spectroscopy • This compound increases the production of short-chain fatty acids and decreases pH values in mouse colon • Some in vivo experiments, using rats, mice, and pigs, demonstrated that 4-Aminobutyric acid can modulate intestinal fluid secretion, blood flow and ulceration |
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