| Customization: | Available |
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| Certification: | ISO, FDA, Hahal, Food Manufacturing License, Business Licens |
| Assay Method: | HPLC, UV |
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| Product Name | Sophora Root Extract |
| Botanical Name | Sophora flavescens Alt |
| Part Used | Root |
| Appearance | Brownish Yellow to White powder |
| Specification | 4:1 10:1 Straight Powder 98% matrine 98% Oxymatrine 98% Sophoridine |
| Storage Period | 24 Months |
| Package | 1kg/bag 25kg/drum |
| Storage Conditions | Store in cool and dry places. Keep away from strong light and heat. |
| Description: Deciduous subshrub, 80~120cm high. The root is cylindrical, the outer skin is yellow, the cross section is yellow and white, and the taste is extremely bitter. Odd pinnate compound leaves, 20~25cm long, alternate; with 11~19 leaflets, leaf blade lanceolate to linear-lanceolate, 3~4cm long, 1.2~2cm wide, apex acuminate, base round, short stalks, entire, densely pubescent on the back; stipules linear. Racemes terminal, short hairs, bracts linear; calyx campanulate, flat, 6~7mm long, 5-lobed; corolla butterfly-shaped, yellowish white; flag petal spatulate, wing petal aurless, equal to the length of keel; stamens 10, filaments separated; ovary stalk with fine hairs. The pods are striped, with a long beak at the apex, and constricted between the seeds, slightly inconspicuous rosary. The flowering period is from June to August and the fruiting period is from August to September. Health Benefits 1. protective effect of gastric mucosa Sophora flavescens extract has obvious protective effect on gastric mucosal injury caused by hydrochloric acid, ethanol and indomethacin, and its main component is flavanone compounds. Recent studies have shown that matrine is also one of the effective components of Sophora flavescens against gastric mucosal injury. It has obvious protective effect on gastric mucosal injury caused by stress, hydrochloric acid, ethanol and indomethacin in rats. It indicates that Sophora flavescens may have some anti-ulcer effect. 2. Anti-inflammatory effect Matrine has obvious antagonistic use of acute exudative inflammation caused by various inflammatory agents (croton oil, glacial acetic acid, carrageenan, egg white), and has similar effects to hydrocortison. Its anti-inflammatory mechanism has nothing to do with the pituitary-adrenal cortex system. Matrine still has a significant anti-inflammatory effect on mice with adrenal glands removed. Studies have shown that this product has the characteristics of non-steroidal anti-inflammatory drugs. In addition, matrine has a stabilizing effect on the red blood cell membrane, and drugs that have a stabilizing effect on the red blood cell often have a stabilizing effect on the lysosomal membrane, thereby reducing the release of inflammatory mediators and achieving anti-inflammatory purposes. 3. Anti-tumor effect Matrine mice were injected intraperitoneally with 500 μg/day, the survival rate was 40%, while the control group all died within 23 days. Oxymatrine has no effect on this. Matrine can reduce the proliferation of P815 tumor cells by mouse peritoneal macrophages in vitro. Sophorine also has anti-cancer activity. Matrine, oxymatrine, sophocarpine and their mixed A, B and C bases in different proportions have different degrees of inhibition on S180 solid tumors. Matrine has a significant inhibitory effect on the colony production rate of peripheral multidirectional hematopoietic progenitor cells in chronic myeloid leukemia. Sophora flavescens decoction acts on human promyelocytic leukemia cells cultured in vitro, which can significantly induce leukemia cells to differentiate into mononuclear macrophages. 4. Leukocyte-increasing effect Oxymatrine can prevent mice from leukopenia caused by MMC and cyclophosphamide. Intravenous or intramuscular injection of matrine and oxymatrine have a significant effect on the number of white blood cells in the peripheral blood of normal rabbits. The effect, maintenance time and peak white blood cell count of oxymatrine on normal rabbits are basically the same within 18 days after administration, the whitening effect is better than shark liver alcohol. 5. Effect on the cardiovascular system Intravenous injection of matrine and oxymatrine significantly resists arrhythmia induced by aconitine and chloroform-epinephrine in rats; intraperitoneal injection significantly resists chloroform-induced ventricular fibrillation in mice, and also increases the amount of aconitine-induced arrhythmia in rats, and resists the arrhythmia induced by barium chloride and the arrhythmia induced by ligating the anterior descending branch of the coronary artery in rats. 6. The effect of relieving asthma and expectorant matrine is mainly through the excitation of β receptors, especially the β receptors in the excitation center, to relieve bronchospasm and inhibit the release of antibodies and slow response substances to produce asthma. 7. The total alkaloids of Sophora flavescens can obviously inhibit the free activity of mice; the passive activity of mice is obviously inhibited; high dose can inhibit the fighting and aggressive behavior of lonely mice. 8. Anti-allergic effect Matrine can reduce the release of allergic mediators, and its concentration of inhibiting 50% OT cell proliferation is 0.55~0.56 mg/ml; The concentration of inhibiting IL-2 yield is 0.1 mg/kg. 9. Immunosuppressive effects Matrine and oxymatrine have inhibitory effects on immune function of mice. 10. Antifungal effect Sophora flavescens decoction has inhibitory effect on common skin fungi. 11. The antibacterial effect of Sophora flavescens extract has inhibitory effect on Staphylococcus, Pseudomonas aeruginosa, Mycobacterium tuberculosis, etc. 12. Effects on the central nervous system Matrine was injected into rabbits, and central nerve paralysis was found, spasm occurred at the same time, and finally respiratory arrest and death. Injected into a frog, it is excited at the beginning, then paralyzed, breathing becomes slow and irregular, and then spasm occurs, so that breathing stops and dies. The onset of spasm may be caused by hyperreflexia in the spinal cord. 13. Antiarrhythmic effect Sophora flavescens has a good antagonistic effect on arrhythmia caused by aconitine, sympathetic amine and digitalis poisoning, and its effect is quite similar to quinidine. That is, by affecting the myocardial cell membrane potassium and sodium conduction system, the absolute refractory period of the myocardium is prolonged, and the stress is reduced, thereby inhibiting the ectopic pacing point and exerting an anti-arrhythmia effect. The active ingredient is preliminarily proved to be the alkaloid part contained. Because Sophora flavescens has no effect on the heart and heart rate of the frog heart and rat myocardium, it does not increase myocardial oxygen consumption and aggravate the shortcomings of heart failure and shock, which is worthy of attention for ischemic heart disease. 14. Toxic effects of oral Sophora flavescens can cause poisoning, symptoms can be seen salivation, irregular pace, faster breathing, pulse, convulsions, and finally death. Rescue method: gastric lavage, catharsis, egg white, tannic acid, strong tea and intravenous glucose saline can be used when convulsions do not occur. Intramuscular injection of phenobarbita and other antispasmodic agents during convulsions, and respiratory stimulants when breathing disorders. |
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