World Well-Being/Chemical/Cosmetics/Skin Care/Arbutin Wholesale/99% Alpha Arbutin

• CAS No.: 84380-01-08
• Formula: C12h16o7
• EINECS: 440-470-8
• Type: Synthesis Material Intermediates
• Appearance: White Powder
• Quality: Industrial
• Model NO.: WWB20231213001
• Colour: White Powder
• Purity: > 97.0%
• Transport Package: Aluminum Foil Bag
• Specification: 99%
• Trademark: World Well-being
• Origin: Hunan
• Production Capacity: 10t/Month

Product Description

Product Name	Alpha Arbutin
Appearance	White Powder
Specification	99%
Grade	Cosmetic

 

Structure and Manufacturing Process:

α-Arbutin is a new type of glucoside with an α-glucosyl bond.

Mechanism of Melanogenesis Inhibition:

The enzyme tyrosinase, one of the key enzymes involved in melanin synthesis, is activated in melanocyte by the stimulation of free radicals induced

from UV irradiation and stress. Its activation triggers melanogenesis, a complex series of enzymatic and chemical reactions, and finally leads to the

formation of freckles and suntan. The inhibitory effect of α-Arbutin on melanogenesis is thought to be due to direct inhibition of melanosomal tyrosinase

activity.

Efficacy:
Inhibitory effects of α-Arbutin on mushroom and human tyrosinases:

 

Arbutin, β-anomer isoform of α-Arbutin, inhibited both mushroom and human tyrosinases. On the other hand, α-Arbutin selectively inhibited only human tyrosinase.

Inhibitory effect of α-Arbutin on human tyrosinase is estimated to be more than ten times stronger than that of arbutin.

Effects of a-Arbutin on melanin production in a three-dimensional human skin model:

α-Arbutin suppresses melanin production that causes freckles and suntan.

 

Darkening of the melanocytes in a three-dimensional human skin model was clearly inhibited by treatment with α-Arbutin.

Melanin production in melanocytes was restored by withdrawal of treatment of α-Arbutin, and no significant difference in cell viability between α-Arbutin.

treated and non-treated tissues was observed. These results suggest that the topical treatment of α-Arbutin decreased melanin synthesis in the human

skin model without affecting cell viability

Effects of a-Arbutin on melanin production in cultured human melanoma cells:

α-Arbutin showed dose-

dependent inhibition of

melanin production in

cultured human melanoma

cells without affecting cell

viability.

Clinical Study of Efficacy for Skin-Lightening:

We evaluated skin-lightening effects by

clinical study involving 60-human

volunteers. The cream containing 1.0 %

α-Arbutin lightened the color of the skin

and it shows better skin-lightening

efficacy than the competitive ingredients,

such as Arbutin and Kojic acid 

within a short time, 1

month. Effects of α-Arbutin were

sustained during the study period, three

months.

Alpha Arbutin Preparation Process:
Company Introduction-Hunan World Well-being Co.,ltd

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