1. Effect on central nervous system In reserpinized mice, the content of hypothalamus NE, striatum DA and brain stem 5-HT can be increased, and the content of 5-HIAA can be decreased. The contents of norepinephrine and acid in hypothalamus and the ratio of norepinephrine to dihydroxyphenylacetic acid could be increased after the ethanol extract of Cistanche deserticola was given to rats for 40 days. It increased dihydroxyphenylacetic acid in striatum to some extent, but had no significant effect on monoamine neurotransmitters in limbic brain region.
2. Regulating endocrine and metabolic effects of cistanche extract can regulate the decrease and increase of nucleic acid content in liver and spleen of animals with Yang deficiency and Yin deficiency. It has the effect of activating the adrenal gland to release corticosteroids; It can enhance the luteinizing function of hypothalamic-pituitary-ovary, improve the responsiveness of pituitary to LRH and the luteinizing function of ovary, improve the responsiveness of pituitary to LRH and the responsiveness of ovary to LH, without affecting the endocrine balance of natural reproductive cycle; Some organic acids of cistanche extract can promote salivary secretion in mice. It can increase the synthesis of liver DNA of yang-deficient animals. Promote RNA synthesis; Improve nucleic acid metabolism of protein; Adding its dilute alcohol extract into water can promote the growth and development of rats. Can extend the life of some animals.
3. Effect on Immune function The weight of spleen and thymus can be increased when the water solution of cistanche deserticola is given to mice at 50-100mg per kg. Increase the phagocytosis rate of macrophages; Increased hemolysin and hemolysin plaque values; The content of cAMP in peritoneal macrophages was increased, while the content of cGMP was decreased. The conversion rate of lymphocytes was increased, and the content of 3H-TdR infiltrated lymphocytes was increased. It can enhance delayed hypersensitivity. Low concentration of cistanche deserticola (5mg/mL) can increase the Ea rosette rate of normal human peripheral blood lymphocytes, but has no effect on Et rosette rate, while high concentration of cistanche deserticola (50mg/mL) can decrease Et rosette rate. Cistanche could decrease the percentage of ANAE+ lymphocytes at high and low concentrations. The mice were given 0.5mL of 60% cistanche decoction for 8 consecutive days to enhance the Chemicalbook effect of foot pad response after SRBC attack.
4. Androgenoid effect The crude extract of cistanche has androgenoid effect, which can increase the weight of secondary sexual organs such as seminal vesicles and prostate. Betaine and ergostane isolated from Cistanche have the same androgenic effect, and the effect of betaine is stronger than that of crude extract. It is speculated that betaine and ergostane are the main active components of androgenic effect of cistanche. The phenylethanol glycosides isolated from this product include ergosterin and improve sexual function.
5. Antioxidant effects Ethanol extract of cistanche deserticola can significantly inhibit the formation of lipid peroxide in rat brain, liver, heart, kidney and testicle tissue homogenate in vitro incubation system, with a dose-effect relationship. Continuous gavage had significant inhibitory effect on the production of lipid peroxide in cerebral cortex of rats, but had no significant effect on other tissues. It significantly enhanced the activity of superoxide dismutase in plasma.
6. Defecation effect of cistanche extract can significantly shorten the defecation time of mice and promote defecation; It can significantly increase the degree of small intestine propulsion and enhance intestinal peristalsis in mice. It can effectively counter the anti-defecation effect of atropine on mice. It can inhibit the water absorption of mouse large intestine.
7. Other effects The alcohol extract of cistanche cistanche can counteract the low sexual behavior and learning ability of male mice caused by chronic suspension stress. It can increase the DNA synthesis rate of liver and spleen in "Yang deficiency" mice. It has obvious inhibitory effect on liver poisoning caused by CCl4. Gavage of water decoction can significantly increase the body weight, prolong the swimming time, improve the hypoxia tolerance, and reduce the increase of serum creatine kinase after load exercise. The Chemicalbook ultrastructure showed that muscle glycogen content was abundant in skeletal muscle, mitochondrial hyperplasia and hypertrophy were common after exercise, and myofibrillar structure was intact without injury. The content of serum urea nitrogen in exercise group was lower than that in control group. There was hyperplasia and hypertrophy of the rough endoplasmic reticulum of the liver. After exercise, there was no obvious "threshing" of ribosomes and expansion of the endoplasmic reticulum pool. It can antagonize protein decomposition, adjust cell ultrastructure and promote protein synthesis. The weight growth rate, freezing resistance time, SOD activity of red blood cells and hemoglobin content of Yang deficiency mice were restored to a certain extent. The use of cistanche alcohol extract in animals with corticosteroids for a long time can prevent adrenal atrophy caused by corticosteroids alone, and also has a certain protective effect on renal function.
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